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Bredford Kerr PDF Print E-mail
Bredford Kerr was born in the city of Antofagasta in 1975. He studied primary and secondary education in the cities of Antofagasta and Arica. In 1994 he joined BA in Biological Sciences to study at the Pontificia Universidad Católica, the degree he got in 1999. In 2000 he entered the doctoral program of the Faculty of Biological Sciences at the same university, he got the academic degree of Dr. in Biological Sciences with a major in Physiology in 2004. Between 2004 and 2007 held a postdoctoral fellow in neuroendocrinology at the Oregon Health and Science University, Oregon, USA, funded by a grant from the Fogarty International Foundation / NIH. In 2007 he returned to Chile and worked in the laboratory of Dr. Juan Young until 2009. It has now begun to form their own working group in Neuroendocrinology. The main lines of research than is currently working are: - Identification of the contribution of different cell types and neuronal populations to the phenotype associated with Rett syndrome. - Changes neuroendocrinological in murine models of neurodevelopmental disorders. -Generation of conditional knockout mice and conditional sobreexpresores for genes related to the functioning of the hypothalamic-pituitary axis, particularly in relation to reproductive function, energy balance and response to stress.
PUBLICACIONES SELECCIONADAS
The absence of Mecp2 induces an increase in body weight associated with altered leptinsignalling in the hypothalamus (2014). Paper accepted for publication in Experimental Physiology EXPPHYSIOL/2014/079798.
Torres-Andrade R, Moldenhauer R, Gutierrez-Bertín N, Soto-Covasich J, Mancilla-Medina C, Ehrenfeld C, and Kerr B.(2007)
Tubular overexpression of Gremlin induces renal damage susceptibility in mice (2014). Paper accepted for publication in PlosOne PONE-D-13-36628R2
Droguett MA, Krall P, Burgos ME, Valderrama G, Carpio D, Ardiles L, Rodriguez- Diez R, Kerr B, Walz K, Ruiz-Ortega M, Egido J and Mezzano S.
Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure (2014). Paper accepted for publication in Endocrinology EN-1111R2.
Dorfman M, García-Rudaz C, Aderman Z, Kerr B, Lomniczi A, Dissen G, Castellano JM, García-Galeano D, Gaytan F, Xu B, Tena-Sempere M and Ojeda SR.
Low physiological levels of prostaglandins E2 and F2alpha improve human sperm functions (2014). Paper accepted for publication in Reproduction, Fertility and Development RD14035.R2
Ríos-Raggio M, Carreño D, Oses C, Barrera N, Kerr B, Villalón M
Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform specific transgenes. Eur J Hum Genet 20(1):60-76.
Kerr B, Soto-Covasich J, Saez MA, Abrams A, Walz K and Young JI. (2012)
Neurotrophins Acting Via TRKB Receptors Activate the JAGGED1-NOTCH2 Cell-Cell Communication Pathway to Facilitate Early Ovarian Development. Endocrinology 152(12):5005-16. * Both authors contributed equally to this work.
Dorfman MD*, Kerr B*, Garcia-Rudaz C, Paredes AH, Dissen GA, Ojeda SR (2011)
Unconventional transcriptional response to environmental enrichment in a mouse model of Rett syndrome. Plos One.5(7):e11534-41.
Kerr B., Silva PA., Walz K. and Young JI. (2010)
NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. Reproduction 138(1):131-40.
Kerr B., Garcia-Rudaz C., Paredes A. and Ojeda SR. (2009)
Defective body weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice. Hum Mol Genet. 17:1707-17.
Kerr B., Alvarez-Saavedra M., Sáez MA., Saona A. and Young JI. (2008)
Brain Derived Neurotrophic Factor regulates expression of D1 dopamine receptor. J. Neuroch. 100:416-28.
Do T., Kerr B., Kuzhikandathil EV. (2007)
Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis. Development 134: 945-57
Luna F., Garcia-Rudaz C., Tapia V., Kerr B., Colgin L, Galimi F., Dissen GA., Ojeda SR. (2007)
NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicle development in the mouse ovary. Article submitted to Reproduction 138:131-40
Kerr B., Garcia-Rudaz MC., Paredes A. and Ojeda SR. (2009)
Defective body weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice. Hum Mol Genet. 17:1707-17.
Kerr B., Alvarez-Saavedra M., Sáez MA., Saona A. and Young JI. (2008)
CONTACT
Telephone : +56-63-234524
Fax : +56-63-234517
E-mail : lc.scec@rrekb