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Bredford Kerr PDF Print E-mail
Bredford Kerr was born in the city of Antofagasta in 1975. He studied primary and secondary education in the cities of Antofagasta and Arica. In 1994 he joined BA in Biological Sciences to study at the Pontificia Universidad Católica, the degree he got in 1999. In 2000 he entered the doctoral program of the Faculty of Biological Sciences at the same university, he got the academic degree of Dr. in Biological Sciences with a major in Physiology in 2004. Between 2004 and 2007 held a postdoctoral fellow in neuroendocrinology at the Oregon Health and Science University, Oregon, USA, funded by a grant from the Fogarty International Foundation / NIH. In 2007 he returned to Chile and worked in the laboratory of Dr. Juan Young until 2009. It has now begun to form their own working group in Neuroendocrinology. The main lines of research than is currently working are: - Identification of the contribution of different cell types and neuronal populations to the phenotype associated with Rett syndrome. - Changes neuroendocrinological in murine models of neurodevelopmental disorders. -Generation of conditional knockout mice and conditional sobreexpresores for genes related to the functioning of the hypothalamic-pituitary axis, particularly in relation to reproductive function, energy balance and response to stress.igenética.


SELECTED PUBLICATIONS
24. Kerr B, Ríos M, Droguett K, Villalón M. Nitric oxide activation by progesterone suppresses ATP-induced ciliary activity in oviductal ciliated cells (2018). Reproduction, Fertility and Development. Article in Press

23. Kerr B, Leiva A, Farías M, Contreras-Duarte S, Toledo F, Stolzenbach F, Silva L, Sobrevía L. Foetoplacental epigenetic changes associated with maternal metabolic dysfunction (2018) Placenta (Review) S0143-4004 (18) 30148-6.

22. Ávalos Y, Kerr B, Maliqueo M and Dorfman M. Cell and molecular mechanisms behind diet-induced hypothalamic inflammation and obesity (2018) J Neuroendocrinol. (Review) (Epub ahead of print) e12598.

21. Torres RF, Hidalgo C and Kerr B. Mecp2 Mediates Experience-Dependent Transcriptional Upregulation of Ryanodine Receptor Type-3 (2017) Fron Mol Neurosci. 10:188

20. Rios M, Carreño DV, Oses C, Barrera N, Kerr B and Villalón M. Low physiological levels of prostaglandins E2 and F2α improve human sperm functions (2016) Reprod Fertil Dev. 28(4):434-9.

19. Martinez G, Vidal RL, Mardonez P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH and Hetz C. Regulation of memory formation by the transcription factor XBP1 (2016) Cell Reports, 14(6):1382-94

18. Oñate M, Catenaccio A, Martinez G, Armentano D, Parson G, Kerr B, Hetz C and Court F. Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury (2016) Scientific Reports, 6:21709

17. Castillo V, Oñate M, Woehlbier U, Rozas P, Andreu C, Medinas D, Valdés P, Osorio F, Mercado G, Vidal RL, Kerr B, Court FA and Hetz C. Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration (2015) PLoS One 10 (9): e0140200.

16. Marchant V, Droguett A, Valderrama G, Burgos ME, Carpio D, Kerr B, Ruiz-Ortega M, Egido J and Mezzano S. Tubular Overexpression of Gremlin in Transgenic Mice Aggravates Renal Damage in Diabetic Nephropathy (2015). American Journal Physiology Renal Physiology 309 (6):F559-68.

15. Torres-Andrade R, Moldenhauer R, Gutierrez-Bertín N, Soto-Covasich J, Mancilla-Medina C, Ehrenfeld C, and Kerr B. The absence of Mecp2 induces an increase in body weight associated with altered leptin signalling in the hypothalamus (2014). Experimental Physiology 99(9):1229-40.

14. Droguett MA, Krall P, Burgos ME, Valderrama G, Carpio D, Ardiles L, Rodriguez-Diez R, Kerr B, Walz K, Ruiz-Ortega M, Egido J and Mezzano S. Tubular overexpression of Gremlin induces renal damage susceptibility in mice (2014). PloS One 9(7):e101879.

13. Dorfman M, García-Rudaz C, Aderman Z, Kerr B, Lomniczi A, Dissen G, Castellano JM, García-Galeano D, Gaytan F, Xu B, Tena-Sempere M and Ojeda SR. Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure (2014). Endocrinology 155(8):3098-111.

12. Kerr B, Soto-Covasich J, Saez MA, Abrams A, Walz K and Young JI. (2012) Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes. Eur J Hum Genet 20(1):60-76.

11. Dorfman MD*, Kerr B*, Garcia-Rudaz C, Paredes AH, Dissen GA, Ojeda SR (2011) Neurotrophins Acting Via TRKB Receptors Activate the JAGGED1-NOTCH2 Cell-Cell Communication Pathway to Facilitate Early Ovarian Development. Endocrinology 152(12):5005-16. * Both authors contributed equally to this work.

10. Kerr B., Silva PA., Walz K. and Young JI. (2010) Unconventional transcriptional response to environmental enrichment in a mouse model of Rett syndrome. Plos One. 5(7):e11534-41.

9. Kerr B., Garcia-Rudaz C., Paredes A. and Ojeda SR. (2009) NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary. Reproduction 138(1):131-40.

8. Kerr B., Alvarez-Saavedra M., Sáez MA., Saona A. and Young JI. (2008) Defective body weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice. Hum Mol Genet. 17:1707-17.

7. De la Chesnaye E., Kerr B., Paredes A., Merchant-Larios H., Mendez JP and Ojeda SR (2007) Mouse ovary.Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary. Biol Reprod. 78:714-25.

6. Luna F., Garcia-Rudaz C., Tapia V., Kerr B., Colgin L, Galimi F., Dissen GA., Ojeda SR. (2007) Fxna, a novel gene differentially expressed in the rat ovary at the time of folliculogenesis, is required for normal ovarian histogenesis. Development 134: 945-57

5. Do T., Kerr B., Kuzhikandathil EV. (2007) Brain Derived Neurotrophic Factor regulates expression of D1 dopamine receptor. J. Neuroch. 100:416-28.

4. Salas C., Julio-Pieper M., Valladares M., Pommer R., Vega M., Mastronardi C., Kerr B., Ojeda SR., Lara HE., Romero C. (2006) Nerve-Growth Factor-dependent activation of TrkA receptors in the human ovary results in synthesis of FSH receptors and estrogen secretion. J Clin Endocrinol Metab. 91:2396-2403.

3. Paredes A., Garcia-Rudaz C., Kerr B., Tapia V., Dissen GA., Costa ME., Cornea A., Ojeda SR. (2005) Loss of SCP1, a synaptonemal complex protein, contributes to the initiation of follicular assambly in the developing rat ovary. Endocrinol. 146: 5267-5277.

2. Morales P., Pizarro E., Kong M., Kerr B., Ceric F., Vigil P. (2000) Gonadotropin-releasing hormone-stimulated sperm binding to the human zona is mediated by a calcium influx. Biol Reprod 63:635-642.

1. Morales P., Kerr B., Oliva C. Pizarro E., Kong M. (1999) Gonadotropin-releasing hormone antagonist inhibit sperm binding to the human zona pellucida. Hum Reprod. 14:2069-2074.

CONTACT
Phone : +56-63-234524
Fax : +56-63-234517
E-mail : lc.scec@rrekb