Felipe Barros PDF Print E-mail
L. Felipe Barros, a graduate from Instituto Nacional, qualified as a Medical Doctor at the University of Chile in 1988, and obtained a PhD from the same university in 1993, advised by David Yudilevich. From 1993 to 1996 he was a Wellcome Trust Fellow in Steve Baldwin´s lab in Leeds, UK, returning in 1996 to the University of Chile as Assistant Professor and then Associate Professor. In 2000, he joined the Centro de Estudios Científicos in Valdivia, where he is now a principal investigator. How are the fluxes of matter, energy and information interwoven in cells and tissues? What is the relationship between metabolism and information in the brain? To tackle these kinds of question, his team is developing new molecular tools, capable of measuring metabolic parameters with high spatiotemporal resolution using light.
Recent Selected Publications
  Fernández-Moncada I, Ruminot I, Robles-Maldonado D, Alegría K, Deitmer JW, Barros LF. Neuronal control of astrocytic respiration through a variant of the Crabtree effect. Proc Natl Acad Sci U S A. in press, 2018.

San Martín A, Arce-Molina R, Galaz A, Pérez-Guerra G, Barros LF. Nanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism. J. Biol. Chem. 292:9432-9438, 2017.

Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B. In vivo evidence for a lactate gradient from astrocytes to neurons. Cell Metabol., 23:94-102, 2016.

Lerchundi R, Fernández-Moncada I, Contreras-Baeza Y, Sotelo-Hitschfeld T, Mächler P, Wyss MT, Stobart J, Baeza-Lehnert F, Alegría K, Weber B, Barros LF. NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting. Proc Natl Acad Sci U S A. 112:11090-5, 2015.

Sotelo-Hitschfeld T, Niemeyer MI, Mächler P, Ruminot I, Lerchundi R, Wyss MT, Stobart J, Fernández-Moncada I, Valdebenito R, Garrido-Gerter P, Contreras-Baeza Y, Schneider BL, Aebischer P, Lengacher S, San Martín A, Le Douce J, Bonvento G, Magistretti PJ, Sepúlveda FV, Weber B, Barros LF. Channel-mediated lactate release by K⁺-stimulated astrocytes. J. Neurosci. 35:4168-78, 2015.
Phone : +56-63-234503
Fax : +56-63-234517
Email : lc.scec@sorrabf